Glucose Intolerance

Glucose intolerance occurs more frequently in persons with Turner Syndrome than in the general population; however, diabetes mellitus seems to be rare. Monitoring of fasting blood glucose concentrations should be considered in girls who are significantly overweight, have a strong family history of type 2 diabetes mellitus, are Hispanic or African American, or have signs of insulin resistance, such as acanthosis nigricans.

Healthy women with Turner Syndrome are characterized by:

    • Impaired glucose tolerance
    • Insulin resistance
    • Low physical capacity
    • Enlarged type IIa muscle fibers, indicating diminished oxygen and substrate supply for metabolic processes
    • These findings could be indicative of a pre-diabetes state

Weight Management

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