The Importance of Weight Management in Turner Syndrome

Turner Syndrome women and girls are at an increased risk for obesity. This is a problem because of the weight-related comorbidities that complicate TS care, including diabetes, elevated cholesterol, liver dysfunction, hypertension, and other cardiovascular complications. The risk of developing type II diabetes is ten-fold in the Turner Syndrome population compared to the general public. The 2017 Clinical Practice Guidelines for the Care of Girls and Women with Turner Syndrome states weight management is the most important health intervention at annual visits, and nutrition counseling and physical activity should begin in early childhood. By maintaining a healthy weight, the risk of developing type II diabetes can be substantially reduced.

An article published in Frontiers in Endocrinology, “The Natural History of Metabolic Comorbidities in Turner Syndrome from Childhood to Early Adulthood: Comparison between 45,X Monosomy and Other Karyotypes,” studied how obesity affects metabolic disorders in children and young adults with Turner Syndrome, specifically in those with 45,X monosomy. Some of the metabolic risk factors starting in childhood include hypertension, impaired glucose metabolism, and hyperlipidemia. Whether these metabolic disorders are inherent to Turner Syndrome is unclear; however, it is clear that obesity impairs the metabolic profile of Turner Syndrome girls. Like the Clinical Practice Guidelines, this article stresses the importance of early detection, routine assessments, and timely interventions of weight and metabolic function. Click below to read the full article and learn more.

LEARN MORE : The natural history of Metabolic comorbidities in Turner syndrome from childhood to early adulthood: comparison between 45,X Monosomy and Other Karyotypes

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